VEGFA and age-related macular degeneration: Therefore, the aim of the current manuscript is to review some of the principal molecular mechanisms associated with the pathogenesis of AMD such as the principal mechanism associated with neovascularization through VEGF signaling, oxidative stress, dysregulation of the mechanisms of clearance of proteins and organelles in AMD (autophagy), the pathophysiology of glial cells in the retina on AMD, and closing each subject of this review explaining some of the new potential treatment alternatives for AMD.