In this context, our interesting finding was an epistatic interaction between SNP rs9332978 of CYP4A11 and SNP rs1558139 of CYP4F2 (this polymorphism was associated with the risk of essential hypertension in Japanese population [19]) in CAD patients suggesting that gene-gene interactions could be involved into the regulation of 20-HETE metabolism and jointly contribute to the development of coronary artery disease. The gene discussed is CYP4A11; the disease is coronary artery disorder.