Nevertheless, based on available publications, the UniProtKB database and Gene Ontology descriptions, we proposed the mechanisms by which loss-of-function polymorphisms rs9332978 and rs1126742 of CYP4A11 are associated with reduced 20-HETE synthase activity and increased risk of coronary artery disease (Figure 1). The gene discussed is CYP4F2; the disease is coronary artery disorder.