It can be assumed that association between rs9332978 of CYP4A11 and CAD susceptibility in women may be related with the inhibitory effect of estradiol on the CYP4A11 expression in the carriers of the variant genotypes, leading to reduced synthesis of 20-HETE and increasing the disease risk through the mechanisms described above. The gene discussed is CYP4A11; the disease is coronary artery disorder.