DNA methylation abnormalities of the H19/IGF2:IG-DMR cause contrasting growth disorders (i.e., Beckwith-Wiedemann syndrome (BWS, MIM#130650) and Silver-Russell syndrome (SRS, MIM#180860)), if they are present on the maternal or paternal chromosome, respectively [2]. This evidence concerns the gene IGF2 and Beckwith-Wiedemann syndrome.