CASP3 and neoplasm: This point was also supported in our findings showing that combined G-Rh2 with SMI-4a could markedly decrease cell viability, promote caspase 3/7 activity, and inhibit melanoma growth over their treatment alone via synergistic effects on autophagy induction, indicating that Rh2 has a synergistic effects on SMI-4a-induced anti-tumor capacity in vitro and in vivo.