Fc-bridged cell-mediated cytotoxicity represents a previously unappreciated mechanism of innate immune cell recognition of and response to a primary viral infection mediated only by the Fc domain of IgG bound to FcγR and recognizing the pathogen expressing an Fc binding protein, as well as naked CD16a recognizing the Fc domain of IgG bound to the infected cell’s Fc-binding protein. Here, FCGR3A is linked to viral infectious disease.