Susceptible alleles of the modifier loci—once again with privileged reference to MHCII ones—are necessary, but not always sufficient, to elicit organ damage: for example, the H2-Aβg7 allele was required to induce autoimmune pancreatitis in NOD Aire−/− mice, but was not sufficient when transferred to a B6 background (282). The gene discussed is AIRE; the disease is autoimmune pancreatitis.