There is a decrease in the percentage of AA, which is associated with an increase of PLA2, COX2/TXs, CYP450 4A and 5-LOX which leads to a greater synthesis of PGE2 than 6-keto-PGF1α thus contributing to the formation of the aortic aneurysm. The gene discussed is ALOX5; the disease is aortic aneurysm.