This chief role of Wnt1 is maintained throught life in the adult midbrain, where Wnt1 contributes to the maintenance of SNpc DA neuron survival, neuronal function and synaptic integrity, in promoting the activation of Nurr1+ post-mitotic mDA neuroprecursors, in favoring neuroprotection and neurorestoration in the injured PD midbrain and up-regulating adult neurogenesis in neurogenic niches, via glia-neuron and glia-NSCs crosstalk (Inestrosa and Arenas, 2010; L'Episcopo et al., 2011a,b, 2012, 2013, 2014a; Galli et al., 2014; Harvey and Marchetti, 2014; Zhang et al., 2015). Here, WNT1 is linked to Parkinson disease.