In addition, Lee et al. investigated the relationship between the NAD-dependent deacetylase sirtuin-3 (SIRT3) protein and mitochondrial function using AD human brain samples, demonstrating that dysfunction of SIRT3 leads to mitochondrial and neuronal damage, and may improve the mitochondrial pathology and neurodegeneration in AD (Lee et al., 2017). Here, SIRT3 is linked to Alzheimer disease.