Peripheral microvascular ED was documented in one-third of RA patients (33.5%); in multiple logistic regression analysis, ACPA negativity and higher triglycerides concentrations were independently associated with the presence of peripheral ED [OR (95% CI) = 1.708 (1.218–2.396), p < 0.01 and OR (95% CI) = 1.005 (1.002–1.009), p < 0.01, respectively]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.