To address this issue, after the exclusion of prediabetes and T2DM from the PCOS cohort (44 women of the 62 noted above), this subset was compared to a group of non-PCOS women with prediabetes (60 women) that showed that the insulin resistance was higher (increased glucose and insulin) in non-PCOS women with prediabetes as expected (p < 0.01); however, in PCOS women it was seen that the HDL was lower and waist/hip ratio was higher in PCOS (p < 0.01) suggesting that those women with PCOS (without IFG) have a more adverse metabolic profile than normal women with IFG. This evidence concerns the gene INS and type 2 diabetes mellitus.