To assess the functional role of cardiac myocyte-specific Hif1-alpha or Hif2-alpha in cardioprotection, we exposed Hif1aloxP/loxP Myosin-Cre+ of Hif2aloxP/loxP Myosin-Cre+ mice to myocardial ischemia and reperfusion injury and measured myocardial injury by infarct size area or serum troponin levels. The gene discussed is EPAS1; the disease is myocardial ischemia.