In order to identify potential target genes that could mediate the cardioprotective role of Hif2a, we performed a microarray study comparing ischemic cardiac tissues from controls or mice with cardiac myocyte-specific deletion of Hif2a. The dominant read-out of this array and confirmatory studies identified an Hif2a-specific induction of the epidermal growth factor Areg during myocardial ischemia. The gene discussed is EPAS1; the disease is myocardial ischemia.