We propose that the anterior diaphragmatic hernia seen in the Tagln-Cre:Tgfbr2flx/flx is probably due to dysfunction in the migration of the TGFβR2+TAGLN+cells at the leading edge of the developing diaphragm similar to what is seen in the developing body wall15. The gene discussed is TAGLN; the disease is congenital diaphragmatic hernia.