Such lack of efficacy has also been noticed for other anti-obesity or anti-diabetic drugs like the GLP1-receptor agonist liraglutide that have no effect on body weight and moderate influence on glucose homeostasis in db/db mice upon two weeks of treatment at 100 μg/kg bid15,16. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.