GLT8D1 and major depressive disorder: Considering the high genetic overlap between SCZ and bipolar disorder (among the five psychiatric disorders, including SCZ, bipolar disorder, attention-deficit/hyperactivity disorder, major depressive disorder, and autism spectrum disorders, SCZ and bipolar disorder have the highest genetic overlap)65, the association between GLT8D1 and bipolar disorder suggests that GLT8D1 may also have a role in SCZ.