Similarly for the aorta, C-fed KO animals showed increased Angiotensinogen and Vegf120 gene expression, and reduced gene expression of Ggcx, Bmp-4, and Gapdh. HF-fed KO animals showed reduced gene expression of Bmp-4 and Gapdh. Therefore the reduction in Bmp-4 and Gapdh gene expression was independent of diet, whereas the other gene expression levels were diet specific. The gene discussed is GAPDH; the disease is hydrops fetalis.