CD4 T lymphocytes can bind to coated EGFL7 through αvβ3 integrin, and this interaction seems to tether cells to the ECM, as we observed CD4+ cells in contact with EGFL7 strands in the ECM in MS lesions, and as KO of EGFL7 was associated with a more efficient migration of CD4+ cells into the CNS parenchyma from the perivascular space compared to control. This evidence concerns the gene EGFL7 and myeloid sarcoma.