Moreover, the pathways closely related to the HIF-1 signaling pathway were selected with the cut off of the degree larger than 3, including focal adhesion, the ErbB signaling pathway, proteoglycans in cancer, the TNF signaling pathway, osteoclast differentiation, leukocyte transendothelial migration, pancreatic cancer, Chagas disease (American trypanosomiasis), central carbon metabolism in cancer, endometrial cancer, and prostate cancer. Here, TNF is linked to American trypanosomiasis.