Then, to provide insights into the effect of hypoxia on ovarian cancer cell proliferation, the genes linked to these signaling pathways were identified, including ErbB2, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD), phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3), endothelin 1 (EDN1), cytochrome b-245 beta chain (CYBB), serpin family E member 1 (SERPINE1) and pyruvate dehydrogenase kinase 1 (PDK1). The gene discussed is EDN1; the disease is ovarian cancer.