In line with previous findings [2], patients with RA who were positive for anti-CCP2 IgG and/or RF IgM were less likely than their negative counterparts to reach initial DFR, although this difference was not significant: 17% of anti-CCP2 IgG positive versus 20% of negative patients (p = 0.14) and 16% of RF IgM positive versus 19% of negative patients (p = 0.43). The gene discussed is CD40LG; the disease is rheumatoid arthritis.