CD40LG and rheumatoid arthritis: Since we selected patients on ACR/EULAR2010 RA criteria, thereby enriching for seropositivity, the differences between anti-CCP2 IgG, RF IgM, and anti-CarP positive and negative patients found here were less pronounced than previously reported in the entire IMPROVED study population because in the current study patients negative for one of these antibodies were by definition positive for another [2].