In microglia, AD heritability was significantly enriched at variants in the OCR motif sets SPI1 (PU.1) (enrichment = 16.28, corrected enrichment P = 4.39 × 10− 3) and Spdef (enrichment = 19.92, corrected enrichment P = 0.040). The gene discussed is SPDEF; the disease is Alzheimer disease.