However, accumulating evidence suggests that certain γδT cell subsets unexpectedly drive tumor development and progression by (i) inducing an immunosuppressive TME and angiogenesis via cytokine production, (ii) interfering with DC effector function, and (iii) inhibiting antitumor adaptive T cell immunity via the PD-1/PD-L1 pathway (reviewed in ref. [86]). The gene discussed is CD274; the disease is neoplasm.