CD8A and neoplasm: Aside from direct cytotoxic effects on tumor cells, some chemotherapeutic agents could induce ICD and activate antitumor immune response through other possible mechanisms: DCs activation and expression of co-stimulatory molecules; enhancement of cross-priming of CD8+ T cells; downregulation of MDSCs and Treg cells activity; promotion of tumor cell death through lytic receptors or pathways; increase in serum inflammatory cytokines and pro-inflammatory changes in TME [153, 154].