Indeed, ACT plus anti-PD-1, anti-PD-L1, or anti-CTLA-4 synergistically reduced tumor growth in the MC38 carcinoma B16 and B16F10 melanoma mouse models [203, 204], and increased the long-term survival in transgenic Her-2 mice upon ACT of Her-2+-specific CAR T cells and anti-PD-1, compared to the monotherapies [205]. Here, CTLA4 is linked to melanoma.