CTLA4 and melanoma: The contribution of radiotherapy and immune­based therapies to efficacy and resistance in patients with melanoma and in mouse models of melanoma was elegantly delineated: the antitumor activity of combined CTLA4 mAbs and radiotherapy was limited by IFN-γ­driven upregulation of PD-L1 expression, whereas the addition of PD-1 blockade markedly increased therapeutic efficacy, suggesting non-redundant mechanisms induced by the different agents [166].