Interestingly, several genes associated with hematopoietic malignancies, including Gata2, Cebpa, Pdk1, Myb, Myc, and Meis1 [44–48], were upregulated in Vav-iCre+, Baf200f/f AML cells (Fig. 8c). Here, VAV1 is linked to acute myeloid leukemia.