Given the role of monocarboxylate transporter 1 (MCT1), a lactate-proton symporter facilitating uptake of lactate into tumor cells in lactate signaling, we used MCT1 inhibitor, a-cyano-4-hydroxycinnamate (CHC), to assess the contribution of MCT1 in lactate-induced Snail protein. Here, SNAI1 is linked to neoplasm.