Activation of PI3K-AKT signaling is a major event in HCC progression [25–27], and recent studies demonstrated that the PI3K-AKT pathway induces EMT in a Snail-dependent manner [28]; thus, we inferred that PI3K-AKT pathway might be the key downstream pathway of NLRX1 which contributed to the suppression function of NLRX1. The gene discussed is SNAI1; the disease is hepatocellular carcinoma.