Similarly, genetic deletion of TXN in MM.1R- and RPMI8226/Dox-BTZ myeloma cells resulted in increased expression of PINK1 and LC3B-II, and the mitochondrial membrane depolarization as measured by JC-1 aggregates (Fig. 5), consistent with the induction of mitophagy. This evidence concerns the gene PINK1 and plasma cell myeloma.