As shown in our previous study, the SET protein is mainly expressed in human theca cells and overexpressed in polycystic ovarian tissues, suggesting that the SET protein regulates ovarian androgen biosynthesis and participates in the pathophysiology of hyperandrogenism in polycystic ovary syndrome (PCOS) (Diao et al., 2004; Gao et al., 2013; Xu et al., 2013a,b). Here, SET is linked to hyperandrogenism.