ALDH2, ITGB2, LGALS3, CTSB, PRDX1, and CD14 were identified as multifunctional proteins that are associated with tumorigenesis, damage, cancer cell death, necrosis, fibrosis, hepatocellular carcinoma, steatosis, and inflammation (Fig 4, panel A and B in S7 Fig). Here, LGALS3 is linked to hepatocellular carcinoma.