ALDH2, ITGB2, LGALS3, CTSB, PRDX1, and CD14 were identified as multifunctional proteins that are associated with tumorigenesis, damage, cancer cell death, necrosis, fibrosis, hepatocellular carcinoma, steatosis, and inflammation (Fig 4, panel A and B in S7 Fig). The gene discussed is CD14; the disease is hepatocellular carcinoma.