Disease-causing recessive or dominant autosomal mutations have been identified, among others, in nephrin (NPHS1),5transient receptor potential channel 6 (TRPC6),6Wilm's tumor suppressor gene 1 (WT1),7 and podocin (NPHS2).8 Most glomerular injuries are, however, not hereditary, but acquired in immune or nonimmune diseases, with 75% of cases having an unknown cause.9 Here, NPHS1 is linked to glycogen storage disease VI.