In the GEO database, sex, age, HBV status, alanine aminotransferase level, primary tumor size, nodal status, BCLC stage, AFP level, and cirrhosis status were analyzed using a multivariate Cox regression model, which showed that CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were not statistically associated with OS or RFS (all P > 0.05, Table 4). This evidence concerns the gene AFP and Cirrhosis.