Many novel serum biomarkers of HCC have been identified in recent years, including osteopontin 52, UQCRH 53, CXCL1 54, integrator complex subunit 6 55, PIVKA–II 56, TIP 30 57, cavin–2 58, and annexin A2 59, among others. The gene discussed is SPP1; the disease is hepatocellular carcinoma.