Second, other potential influencing factors regarding tumor evolution and prognosis, such as drinking status, smoking status, cirrhosis status, Child–Pugh score, tumor number, primary tumor size, pathological differentiation diagnosis, tumor capsule status, and vascular invasion should be included for analysis to better evaluate the relationships between CYP2C subfamily members and HCC prognosis. The gene discussed is CYP2C18; the disease is neoplasm.