Moreover, CYP2C9 is reportedly associated with the risk of colorectal cancer 16, while CYP2C18 was found to have no contribution to cancer risk 11 and CYP2C19 has been associated with peptic ulcer disease 17, colorectal adenoma recurrence 18, breast cancer 19, and cardiovascular diseases 20. This evidence concerns the gene CYP2C18 and cancer.