The PTHrP resembles parathyroid hormone as they both have the common first 13 N-terminal amino acids, and PTHrP binds to parathyroid hormone receptors adversely activating various organs with most of the damage to the bones with its osteolytic action resulting in hypercalcemia.11 Squamous cell carcinoma of the anogenital area is usually a slow growing tumor, but the rate of tumor progression in our patient within the past few months could suggest an aggressive phenotypic change. Here, PTHLH is linked to Hypercalcemia.