Another independent screening study identified small molecules PRIMA-1 and MIRA-1 that covalently modify the thiol groups of one or more cysteine residues in the mutant p53 core domain, restoring the wild-type conformation, and tumor suppressor function of mutant p53 (Bykov et al., 2005; Lambert et al., 2009). Here, TP53 is linked to neoplasm.