Aberrant activation of NF-κB has been linked with a variety of solid tumors (breast, prostate, lung, and pancreatic cancers), in a number of hematopoietic cancers (likes of multiple myeloma, chronic myelogenous leukemia, and Hodgkin's and non-Hodgkin's lymphomas) and multiple human immunological diseases (including incontinentia pigmenti, ectodermal dysplasia coupled with immunodeficiency, chronic autoinflammation, and muscular amylopectinosis; Popovic et al., 2014). Here, NFKB1 is linked to AL amyloidosis.