Restoration of wild-type p53 expression by disrupting p53-MDM2 interaction certainly holds great potential in triggering cell death and eliminates tumors in vivo but with the p53 mutation occurring frequently in human tumors, it also plays a critical role in tumor evolution by allowing evasion from apoptosis as mutated p53 is no longer ubiquitinated by MDM2 and becomes stabilized (Lukashchuk and Vousden, 2007). The gene discussed is TP53; the disease is neoplasm.