MDM2 and neoplasm: Restoration of wild-type p53 expression by disrupting p53-MDM2 interaction certainly holds great potential in triggering cell death and eliminates tumors in vivo but with the p53 mutation occurring frequently in human tumors, it also plays a critical role in tumor evolution by allowing evasion from apoptosis as mutated p53 is no longer ubiquitinated by MDM2 and becomes stabilized (Lukashchuk and Vousden, 2007).