Other significantly mutated genes included histone-modifiers KDM5C and KDM6A, previously implicated in ccRCC (17–19, 22), genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway, such as mechanistic target of rapamycin (mTOR), PIK3CA, and PTEN, as well as TCEB1 (Elongin C) (16, 21). The gene discussed is PIK3CA; the disease is nonpapillary renal cell carcinoma.