Interleukin-1-beta gene expression decreased in the spleen due to leptin deficiency (log-transformed; F1,26 = 6.390; p = 0.02), although after conducting post-hoc tests, only ob SF mice exhibited significantly lower levels than wild-type SF controls (Fisher’s LSD; p < 0.05). This evidence concerns the gene IL1B and hyperinsulinemic hypoglycemia, familial, 4.