Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease. This evidence concerns the gene FOXE1 and hypothyroidism, congenital, nongoitrous, 2.