NOS1 and Duchenne muscular dystrophy: The protein α-dystrobrevin, which binds to both syntrophins and dystrophin,28–30 is a substrate for tyrosine kinases,31 and is required for proper localization of nNOS to the sarcolemma.30 Loss of dystrophin in both DMD patients and DMD animal models causes nNOS to mislocalize to the cytosol.32