INS and diabetes mellitus: Generally, current therapeutic strategies for this type of diabetes are limited and involve insulin and four main classes of oral antidiabetic agents that stimulate pancreatic insulin secretion (sulphonylureas and rapid-acting secretagogues/insulinotropics), reduce hepatic glucose production (biguanides), delay digestion and absorption of intestinal carbohydrate (α-glucosidase inhibitors), or improve insulin action [thiazolidinediones (TZDs)] [2].