SMURF2 and neoplasm: SMURF2 has a key role in Ubiquitin E3 ligase regulation of the TGF-beta pathway (Jin K. et al., 2017) and was found significantly down-regulated (four-fold, P = 1.5e-246 by Wald test in DESeq2 package) in SW620 metastatic cells relative to SW480 primary tumor cells (Table S4).