Although JMJD2A and JMJD2C are histone demethylases for H3K9 and H3K36 belonging to the same protein family (Lizcano and Garcia, 2012), our study demonstrates that JMJD2A and JMJD2C have opposite expression patterns when cardiac hypertrophy is induced. Here, KDM4C is linked to cardiac hypertrophy.