To characterize the role of eosinophils, neutrophils, mast cell granular proteins, and lipid mediators in Ss infection, we measured the plasma levels of eosinophil granular proteins (ECP, EDN, EPX, and MBP), neutrophil granular proteins (NE, MPO, and PTN-3), mast cell granular proteins, and lipid mediator (MCT, LTC4, and CPA-3) in INF and UN individuals. This evidence concerns the gene RNASE3 and synovial sarcoma.