Comprehensive investigations in mice have suggested that a population of NK-cells, uniquely expressing the IL-6 receptor alpha and colony-stimulating factor 1 receptor (IL6Ra+Csf1r+), induced via IL-6/STAT-3 (signal transducer and activator of transcription-3) signalling, accumulate with obesity within visceral adipose tissue (95). The gene discussed is IL6R; the disease is Obesity.