Furthermore, the in vitro and in vivo function of VitC-treated Treg has not yet been studied, considering that Nikolouli’s report only describes the role of VitC on TGF-β+ RA-iTreg differentiated in the presence of allogeneic APCs (without declaring a potential effect of both vitamins on the APCs or the secretion of vitamins from APCs). This evidence concerns the gene TGFB1 and rheumatoid arthritis.