CHRNA4 and Alzheimer disease: Recently, in an animal model of AD [lipopolysaccharide(LPS)-induced neuroinflammation in rats] it was tested the combination of PNU-120596, a positive allosteric modulator (PAM) of α7 nicotine acetyl choline receptor (nAChR), with the specific nAChR agonist PNU-282987 or with TQ (Ibrahim AbdEl Fattah et al., 2016).