MBTPS1 and cancer: S1P signaling has been known to be involved in many types of pain, e.g., inflammatory pain (Lai et al., 2008; Mair et al., 2011), postsurgical pain (Camprubí-Robles et al., 2013), cancer-induced bone pain (Grenald et al., 2017) and chemotherapy-induced neuropathic pain (Janes et al., 2014).