RHOA and neuroblastoma: Previous studies in N1E-115 neuroblastoma cells have demonstrated the requirement of RhoA for the activation of Gα13-mediated chloride conductance by bioactive lipids such as lysophosphatidic acid (LPA) and S1P (Postma et al., 2001; Ponsioen et al., 2009), and we recently found S1P induced the activation of RhoA in sensory neurons (Quarta et al., 2017).