CADM1 and autism spectrum disorder: For example, gene variants of SynCAMs, which possess three extracellular Ig-like domains as IgLON proteins, have been identified as causal or risk factors for intellectual disability and autism spectrum disorders and SynCAM-deficient mice exhibit social and emotional deficits (Frei and Stoeckli, 2017; Gennarini and Furley, 2017).