VCP and amyotrophic lateral sclerosis: Other familial ALS mutation phenotypes, such as valosin-containing protein (VCP) (Hall et al., 2017), TAR DNA-binding protein 43 (TDP-43) (Serio et al., 2013; Barmada et al., 2014), and superoxide dismutase (SOD1) (Bhinge et al., 2017), have been recapitulated in iPSCs showing characteristic proteinopathies, and endoplasmic reticulum (ER) and oxidative stress.