The wide-spread mis-regulation of immune response related genes such as Toll-like receptors (TLRs), complement components, cytokines, caspases, and tumor suppressors was a dramatic side effect of injecting control or t/t2 MOs, since their induction or suppression was unique to morphants, and their local chromatin environment in early tailbud embryos did not show any chromatin occupancy of Brachyury (t) as detected by chromatin immunoprecipitation sequencing (Gentsch et al., 2013) in contrast to the Brachyury-dependent core regulatory network (Figure 3A). Here, TBX1 is linked to neoplasm.