HSP90AA1 and cancer: It has also been reported that FGFRs, and in particular FGFR3, are clients for the Cdc37/Hsp90 chaperone machinery in various cellular systems and that the dependence on the chaperone is further enhanced for some cancer-associated FGFR gene fusion products (Acquaviva et al., 2014, Jin et al., 2011, Laederich et al., 2011, Taipale et al., 2012).