ERBB2 and breast cancer: In oncogene-driven mammary tumor models, such as the MCF-10A, MCF7, MDA-MB-231, and MDA-MB157 cell lines and (MMTV)-ErbB2, MMTV-Myc, and MMTV-Wnt transgenic mice, SOD1 is overexpressed in 60–100% of cases (273), suggesting that SOD1 activation is not linked to a specific oncogene and does not solely depend on oncogene activation.