In addition, increased SOD2 expression is correlated with an increased epithelial–mesenchymal transition (EMT) score in different breast cancer subtypes, whereas the RNAi silencing of SOD2 decreases EMT-related protein (VIMENTIN, β-CATENIN, SLUG, N-CADHERIN, TWIST, zinc finger E-box binding homeobox 2 [ZEB2], and SNAIL) expression (126, 165, 175, 207), strongly suggesting a stimulatory role for SOD2 in cancer cell migration and metastasis. This evidence concerns the gene SOD2 and cancer.