Although all five splice variants are expressed in vascular endothelial and smooth muscle cells (20, 154), the expression of the splice variants shows also tissue-specific expression pattern: NOX5α is mainly expressed in the spleen, NOX5β is mainly expressed in the testis, and truncated NOX5ɛ is mainly expressed in esophageal cancer (15, 50, 94, 96). The gene discussed is NOX5; the disease is esophageal cancer.