In addition to the transformation effect in colon, breast, prostate, lung, and in ovarian cancer cells (5, 102, 240, 342), the increased tumorigenicity of NADPH oxidase NOX1 is mediated through angiogenic stimuli by the upregulation of vascular endothelial growth factor (VEGF) expression and the phosphorylation of VEGF receptors VEGFR-1 and VEGFR-2 (12). The gene discussed is VEGFA; the disease is ovarian cancer.