The expression of NOX4, which in the normal thyroid is −0.37 similar to the level of NOX2, shows a moderate but significant increase in follicular carcinoma (−0.22; p < 0.05), oncolytic adenoma (−0.15; p < 0.05), and especially in papillary thyroid carcinoma (0.04; p < 0.01), characterized by desmosplastic stroma development (Fig. 9). This evidence concerns the gene CYBB and differentiated thyroid carcinoma.