Inhibition of the NFκB signal transduction pathway by the kinesin spindle protein inhibitor SB715992 (1 nM concentration) in human multiple myeloma cells results in reduced SOD2 expression and induces cell death in 24 h (335), therefore confirming the role of NFκB in SOD2 stimulation and suggesting a growth-supportive role for the enzyme. Here, NFKB1 is linked to plasma cell myeloma.