Indeed, RNA interference (RNAi) silencing of NOX5α and the use of O2•−-neutralizing N-acetyl cysteine (NAC) and diphenyleniodonium (DPI) inhibited prostate cancer and leukemia cell proliferation in vitro and tumorigenesis in vivo, demonstrating NOX5α-driven cancer cell growth (136, 328, 331). This evidence concerns the gene NOX5 and cancer.