Indeed, a recent development of immunotherapy by disrupting the connection of programmed death 1 (PD-1), expressed by T cells, and the ligand programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2), expressed by cancer cells, disrupts a crucially important signaling cascade meant to prevent tumor escape from immune destruction (79). Here, PDCD1LG2 is linked to neoplasm.