NOX5 and esophageal adenocarcinoma: NOX5 has been further shown to support growth and cell proliferation via the PDGF-JAK2-STAT pathway in vascular smooth muscle cells, via the NFκB-COX2-PGE2 pathway in esophageal adenocarcinoma cells, and via the SHP2-tyrosine PO4 pathway in hairy cell leukemia (96, 154).