BRCA2 and breast carcinoma: Breast cancer risk factors are frequently associated with oxidative stress-linked phenomena, such as aging, obesity, smoking, or alcohol consumption, and the pedigree of patients, which is the basis for the hereditary breast/ovarian syndrome that can be caused by mutations in BREAST CANCER 1 (BRCA1), BRCA2, and TP53 tumor suppressor genes (215, 238).