PRDM16 and obesity due to melanocortin 4 receptor deficiency: Patil et al recently showed that the adipose tissue-specific overexpression of the transcription factor ID1 (inhibitor of differentiation 1) caused an HFD-induced obesity by diminishing Prdm16. ID1 interacts with early B cell factor 2 (EBF2), thereby suppressing its transcriptional activity and resulting in reduced expression of Prdm16 [33].