Single-photon emission computed tomography (SPECT) imaging of the dopamine transporter (DAT), which is intensively expressed in the striatum, is widely used in clinical practice to support the diagnosis of dopaminergic degenerative movement disorders such as Parkinson’s disease [1] and the differentiation of dementia with Lewy bodies and Alzheimer’s disease [2]. Here, SLC6A3 is linked to early-onset autosomal dominant Alzheimer disease.